MyBioSource.com's Anti-Mouse/Rat CD81, Purified (Clone Eat2) (mouse IgG1) is a Hamster monoclonal antibody. The Anti-Mouse/Rat CD81, Purified (Clone Eat2) (mouse IgG1) Antibody was generated using CD81, and TSPAN28 as the antigen. It reacts with Mouse, and Rat. This antibody has been shown to work in applications such as: Immunohistochemistry.
Description
MBS520207 reacts with the extracellular loops of murine CD81 (TAPA- 1) molecule. As a member of the tetraspanin superfamily of cell-surface proteins, CD81 has been linked to the control of cell proliferation, adhesion and motility. CD81 is expressed in higher levels on resting murine B cells than on resting T cells and is functionally active on B cells as it induces homotypic adhesion of B lymphocytes. Unlike human CD81, which is expressed equally on all thymocytes, murine CD81 is upregulated on CD4+CD8+ thymocytes, then down-regulated again on mature single-positive thymocytes. Murine dendritic cells, splenic macrophages and non-killer cells all express very high levels of CD81. CD81 has also been involved in the induction of IL-4 secretion from T cells during Th2 immune responses. It has been reported that CD81 expression can also be induced in mature T cells upon activation. This anti-CD81 mAb has been shown to decrease the proliferation of LPS stimulated CD81+/+ B cells to levels similar to that of CD81-/ - B cells